Aldosterone mediates its results on electrolyte and renal homeostasis by binding to the MR receptors on principal epithelial cells in the renal cortical gathering duct. Sodium is reabsorbed via the ENaC (epithelial sodium channel) about the apical membranes of principal cells during the gathering tubules. Aldosterone contributes to improved concentrations of ENaC channels at the apical membrane, leading to increased sodium reabsorption.

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Besides the key physiological functions, the RAAS has an important purpose while in the pathophysiological situations of hypertension, coronary heart failure, other cardiovascular illnesses, and renal disorders.

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